1. Therapeutic potency of substituted chromones as Alzheimer’s drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation

Prayasee Baruah, Mostofa Ataur Rohman, Semen O. Yesylevskyy, Sivaprasad Mitra*

Bioimpacts. 2019;9(2): 79-88. doi: 10.15171/bi.2019.11

PMCID: PMC6637216 PMID: 31334039 Scopus ID: 85067466464

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Two chromone derivatives, CyC and AMC exhibit strong non-competitive acetylcholinesterase (AChE) inhibition. CyC, due to planarity and greater stacking interactions with Peripheral Anionic Site, is the stronger AChE antagonist and plasma protein binder.

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